OPTOGENETIC MODULATION OF GUANINE NUCLEOTIDE EXCHANGE FACTORS OF RAS SUPERFAMILY PROTEINS DIRECTLY CONTROLS CELL SHAPE AND MOVEMENT

Optogenetic modulation of guanine nucleotide exchange factors of Ras superfamily proteins directly controls cell shape and movement

In this article, we provide detailed protocols on using optogenetic dimerizers to acutely perturb activities of guanine nucleotide exchange factors (GEFs) specific to Ras, Rac or Rho small GTPases of the migratory networks in various mammalian and amoeba cell lines.These GEFs are crucial components of signal transduction networks which link upstrea

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The relationship between severity of hemorrhoid symptoms and quality of life in Postpartum Women with Grade I and II Internal Hemorrhoid

c6 corvette door handle Introduction: The hemorrhoid is referred to dilated parts of the anal canal veins, which help to control fecal excretion and is one of the most common digestive diseases.Since postpartum problems such as hemorrhoid have significant effect on physical health and psychological well-being, lactation, baby care, and communicatio

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Courage and Heroism of Soviet Soldiers in the Battle of Kursk

The appeal to this topic is due to the 80th anniversary of the victory hot wheels octo car wash at the Kursk Bulge (August 23, 2023), as well as the conduct of a special military operation.The Battle of Kursk demonstrated the morale, unity and will of the multinational Soviet people in defending their Fatherland.Only on the Kursk Bulge 248 servicem

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Predicting the Air Quality Index of Industrial Areas in an Industrialized City in India Using Adopting Markov Chain Model

Introduction: The rapid urbanization coupled with industrial development in Indian cities has led to air pollution that causes adverse effects on the health of human beings.So, it is crucial to track the quality of air reebok classic grün in industrial areas of a city to insulate the public from harmful air pollutants.The present study examined an

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